Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter

被引：14

作者：

Bailey, PD

Boyd, CAR

Collier, ID

Kellett, GL

Meredith, D

Morgan, KM

Pettecrew, R

Price, RA

机构：

[1] Univ Manchester, Sch Chem, Manchester M60 1QD, Lancs, England

[2] Univ Oxford, Dept Human Anat & Genet, Oxford OX1 3QX, England

[3] Heriot Watt Univ, Dept Chem, Edinburgh EH14 4AS, Midlothian, Scotland

[4] Univ York, Dept Biol Area 3, York YO1 5DD, N Yorkshire, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2005年 / 3卷 / 22期

基金：

英国惠康基金;

关键词：

D O I：

10.1039/b513274f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereochemistry of thiodipeptides of proline [e.g. Ala-psi[CS-N]-Pro] can be controlled using pH, allowing the trans-preference for substrates of the peptide transporter PepT1 to be confirmed.

引用

页码：4038 / 4039

页数：2

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