Counting the Founders: The Matrilineal Genetic Ancestry of the Jewish Diaspora

被引:84
作者
Behar, Doron M. [1 ]
Metspalu, Ene [2 ]
Kivisild, Toomas [2 ,3 ]
Rosset, Saharon [4 ]
Tzur, Shay [1 ,5 ]
Hadid, Yarin [1 ,5 ]
Yudkovsky, Guennady [5 ]
Rosengarten, Dror [5 ]
Pereira, Luisa [6 ,7 ]
Amorim, Antonio [6 ,8 ]
Kutuev, Ildus [2 ,9 ]
Gurwitz, David [10 ]
Bonne-Tamir, Batsheva [10 ]
Villems, Richard [2 ]
Skorecki, Karl [1 ,5 ]
机构
[1] Mol Med Lab, Haifa, Israel
[2] Univ Tartu, Estonian Bioctr, Dept Evolut Biol, Tartu, Estonia
[3] Univ Cambridge, Leverhulme Ctr Human Evolut Stud, Cambridge, England
[4] IBM TJ Watson Res Ctr, Data Analytics Res Grp, Yorktown Hts, NY USA
[5] Israel Inst Technol, Res Inst, Rappaport Fac Med, Haifa, Israel
[6] IPATIMUP, Oporto, Portugal
[7] Univ Porto, Fac Med, Oporto, Portugal
[8] Univ Porto, Fac Ciencias, Oporto, Portugal
[9] Russian Acad Sci, Ufa Res Ctr, Inst Biochem & Genet, Ufa, Russia
[10] Sackler Sch Med, Dept Human Genet, Ramat Aviv, Israel
来源
PLOS ONE | 2008年 / 3卷 / 04期
基金
以色列科学基金会;
关键词
D O I
10.1371/journal.pone.0002062
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The history of the Jewish Diaspora dates back to the Assyrian and Babylonian conquests in the Levant, followed by complex demographic and migratory trajectories over the ensuing millennia which pose a serious challenge to unraveling population genetic patterns. Here we ask whether phylogenetic analysis, based on highly resolved mitochondrial DNA ( mtDNA) phylogenies can discern among maternal ancestries of the Diaspora. Accordingly, 1,142 samples from 14 different non-Ashkenazi Jewish communities were analyzed. A list of complete mtDNA sequences was established for all variants present at high frequency in the communities studied, along with high-resolution genotyping of all samples. Unlike the previously reported pattern observed among Ashkenazi Jews, the numerically major portion of the non-Ashkenazi Jews, currently estimated at 5 million people and comprised of the Moroccan, Iraqi, Iranian and Iberian Exile Jewish communities showed no evidence for a narrow founder effect, which did however characterize the smaller and more remote Belmonte, Indian and the two Caucasus communities. The Indian and Ethiopian Jewish sample sets suggested local female introgression, while mtDNAs in all other communities studied belong to a well-characterized West Eurasian pool of maternal lineages. Absence of sub-Saharan African mtDNA lineages among the North African Jewish communities suggests negligible or low level of admixture with females of the host populations among whom the African haplogroup (Hg) L0-L3 sub-clades variants are common. In contrast, the North African and Iberian Exile Jewish communities show influence of putative Iberian admixture as documented by mtDNA Hg HV0 variants. These findings highlight striking differences in the demographic history of the widespread Jewish Diaspora.
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页数:16
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