Primary Amines as Directing Groups in the Ru-Catalyzed Synthesis of Isoquinolines, Benzoisoquinolines, and Thienopyridines

被引：98

作者：

Villuendas, Pedro ^{[1
]}

Urriolabeitia, Esteban P. ^{[1
]}

机构：

[1] Univ Zaragoza, CSIC, Inst Sintesis Quim & Catalisis Homogenea, E-50009 Zaragoza, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 11期

关键词：

H BOND ACTIVATION; RUTHENIUM(II) COMPLEXES; OXIDATIVE ANNULATION; INTERNAL ALKYNES; CARBON-CARBON; O BOND; C BOND; DERIVATIVES; MECHANISM; CYCLOMETALATION;

D O I：

10.1021/jo400344m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isoquinolines, benzoisoquinolines, thieno[3,2-c]pyridines and fused heteroaryl[2,3-c] pyridines, with a wide variety of substituents at different positions of the aromatic or heteroaromatic rings, have been synthesized by Ru-catalyzed oxidative coupling of a broad range of benzylamines or heterocycles with internal alkynes. All benzylamines and heterocycles have unprotected primary amines as efficient directing groups.

引用

页码：5254 / 5263

页数：10

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