Cationic Ruthenium(II) Catalysts for Oxidative C-H/N-H Bond Functionalizations of Anilines with Removable Directing Group: Synthesis of Indoles in Water

被引：323

作者：

Ackermann, Lutz ^{[1
]}

Lygin, Alexander V. ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 03期

关键词：

REACTION SEQUENCE; DIRECT ARYLATIONS; PALLADIUM; ACTIVATION; ALKYNES; ANNULATION; CONSTRUCTION; COMPLEXES; ARENE;

D O I：

10.1021/ol203309y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cationic ruthenium(II) complexes enabled oxidative C-H bond functionalizations with anilines bearing removable directing groups. The C-H/N-H bond cleavages occurred most efficiently in water as a sustainable solvent and provided general access to various bioactive indoles. Mechanistic studies provided strong support for a novel reaction manifold.

引用

页码：764 / 767

页数：4

共 49 条

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Ackermann, L
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Ackermann, Lutz
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[5] Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles
Ackermann, Lutz
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Ackermann, Lutz
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[J]. ORGANIC LETTERS, 2011, 13 (16) : 4153 - 4155
[7] Ruthenium-Catalyzed Oxidative Annulation by Cleavage of C-H/N-H Bonds
Ackermann, Lutz
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[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (28) : 6379 - 6382
[8] Ruthenium-Catalyzed Direct C-H Bond Arylations of Heteroarenes
Ackermann, Lutz
Lygin, Alexander V.
[J]. ORGANIC LETTERS, 2011, 13 (13) : 3332 - 3335
[9] Ruthenium-Catalyzed Oxidative Synthesis of 2-Pyridones through C-H/N-H Bond Functionalizations
Ackermann, Lutz
Lygin, Alexander V.
Hofmann, Nora
[J]. ORGANIC LETTERS, 2011, 13 (12) : 3278 - 3281
[10] Carboxylate-Assisted Transition-Metal-Catalyzed C-H Bond Functionalizations: Mechanism and Scope
Ackermann, Lutz
[J]. CHEMICAL REVIEWS, 2011, 111 (03) : 1315 - 1345

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