Intrapulmonary, adenovirus-mediated overexpression of KARAP/DAP12 enhances fungal clearance during invasive aspergillosis

被引：5

作者：

Carpenter, KJ

Buckland, KF

Xing, Z

Hogaboam, CM

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 12期

关键词：

D O I：

10.1128/IAI.73.12.8402-8406.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.

引用

页码：8402 / 8406

页数：5

共 38 条

[11] Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus
Bozza, S
Gaziano, R
Spreca, A
Bacci, A
Montagnoli, C
di Francesco, P
Romani, L
[J]. JOURNAL OF IMMUNOLOGY, 2002, 168 (03) : 1362 - 1371
[12] Menacing mold:: The molecular biology of Aspergillus fumigatus
Brakhage, AA
Langfelder, K
[J]. ANNUAL REVIEW OF MICROBIOLOGY, 2002, 56 : 433 - 455
[13] Time-varying risk and return in the bond market: A test of a new equilibrium pricing model
Campbell, CJ
Kazemi, HB
Nanisetty, P
[J]. REVIEW OF FINANCIAL STUDIES, 1999, 12 (03) : 631 - 642
[14] TREM-1 (triggering receptor expressed on myeloid cells): A new player in acute inflammatory responses
Colonna, M
Facchetti, F
[J]. JOURNAL OF INFECTIOUS DISEASES, 2003, 187 : S397 - S401
[15] Trems in the immune system and beyond
Colonna, M
[J]. NATURE REVIEWS IMMUNOLOGY, 2003, 3 (06) : 445 - 453
[16] Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia
Gibot, S
Cravoisy, A
Levy, B
Bene, MC
Faure, G
Bollaert, PE
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (05) : 451 - 458
[17] Plasma level of a triggering receptor expressed on myeloid cells-1:: Its diagnostic accuracy in patients with suspected sepsis
Gibot, S
Kolopp-Sarda, MN
Béné, MC
Cravoisy, A
Levy, B
Faure, GC
Bollaert, PE
[J]. ANNALS OF INTERNAL MEDICINE, 2004, 141 (01) : 9 - 15
[18] Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309
Inngjerdingen, M
Damaj, B
Maghazachi, AA
[J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (08) : 4048 - 4054
[19] Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice
Jakubzick, C
Wen, HT
Matsukawa, A
Keller, M
Kunkel, SL
Hogaboam, CM
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (04) : 1211 - 1221
[20] CCL17 and IL-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages
Katakura, T
Miyazaki, M
Kobayashi, M
Herndon, DN
Suzuki, F
[J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (03) : 1407 - 1413

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