Wnt/β-Catenin Signaling and Disease

被引：4865

作者：

Clevers, Hans ^{[1
,2
]}

Nusse, Roel ^{[3
,4
]}

机构：

[1] KNAW, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, NL-3584 CT Utrecht, Netherlands

[3] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Dev Biol, Sch Med, Stanford, CA 94305 USA

来源：

CELL | 2012年 / 149卷 / 06期

关键词：

RECEPTOR-RELATED PROTEIN-5; CANCER STEM-CELLS; GLYCOGEN-SYNTHASE KINASE-3; SMALL-MOLECULE INHIBITORS; NUCLEAR BETA-CATENIN; HAIR FOLLICLE; REQUIRES RETROMER; GENE-PRODUCT; WNT PROTEINS; COLORECTAL-CANCER;

D O I：

10.1016/j.cell.2012.05.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/beta-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

引用

页码：1192 / 1205

页数：14

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