STING Recognition of Cytoplasmic DNA Instigates Cellular Defense

被引：228

作者：

Abe, Takayuki ^{[1
,2
]}

Harashima, Ai ^{[1
,2
]}

Xia, Tianli ^{[1
,2
]}

Konno, Hiroyasu ^{[1
,2
]}

Konno, Keiko ^{[1
,2
]}

Morales, Alejo ^{[1
,2
]}

Ahn, Jeonghyun ^{[1
,2
]}

Gutman, Delia ^{[1
,2
]}

Barber, Glen N. ^{[1
,2
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Cell Biol, Miami, FL 33136 USA

[2] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA

来源：

MOLECULAR CELL | 2013年 / 50卷 / 01期

关键词：

CYCLIC DI-GMP; INNATE IMMUNE-RESPONSE; ADAPTER; SENSOR; REVEALS; IFI16;

D O I：

10.1016/j.molcel.2013.01.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How the cell recognizes cytosolic DNA including DNA-based microbes to trigger host-defense-related gene activation remains to be fully resolved. Here, we demonstrate that STING (stimulator of interferon genes), an endoplasmic reticulum translocon-associated transmennbrane protein, acts to detect cytoplasmic DNA species. STING homodimers were able to complex with self- (apoptotic, necrotic) or pathogen-related ssDNA and dsDNA and were indispensible for HSV-1-mediated transcriptional activation of a wide array of innate immune and proinflammatory genes in addition to type I IFN. Our data indicate that STING instigates cytoplasmic DNA-mediated cellular defense gene transcription and facilitates adoptive responses that are required for protection of the host. In contrast, chronic STING activation may manifest inflammatory responses and possibly autoinnmune disease triggered by self-DNA.

引用

页码：5 / 15

页数：11

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