Rhodium(III)-Catalyzed Intramolecular Hydroarylation, Amidoarylation, and Heck-type Reaction: Three Distinct Pathways Determined by an Amide Directing Group

被引：143

作者：

Davis, Tyler A. ^{[1
]}

Hyster, Todd K. ^{[1
]}

Rovis, Tomislav ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 52期

关键词：

amidoarylation; C-H activation; Heck-type reaction; hydroarylation; rhodium; H BOND ACTIVATION; AROMATIC IMINES; N-METHOXYBENZAMIDES; CONJUGATE ADDITION; ORTHO-ALKYLATION; MILD CONDITIONS; ANNULATION; FUNCTIONALIZATION; ALKENES; OLEFINATION;

D O I：

10.1002/anie.201307631

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The amide decides: Three different rhodium(III)-catalyzed reaction pathways of a wide variety of tethered alkenes can be accessed through changing the amide directing group. This provides an efficient route to a myriad of complex polycyclic products, many containing newly formed all-carbon quaternary centers. Amidoarylations can diastereoselectively deliver products with up to three contiguous stereocenters. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：14181 / 14185

页数：5

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