Localization of opioid-binding cell adhesion molecule (OBCAM) in adult rat brain

被引：8

作者：

Hachisuka, A ^{[1
]}

Nakajima, O ^{[1
]}

Yamazaki, T ^{[1
]}

Sawada, J ^{[1
]}

机构：

[1] Natl Inst Hlth Sci, Div Biochem & Immunochem, Tokyo 158, Japan

来源：

BRAIN RESEARCH | 1999年 / 842卷 / 02期

关键词：

opioid-binding cell adhesion molecule; OBCAM; adult rat; distribution; localization; immunostaining;

D O I：

10.1016/S0006-8993(99)01831-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the tissue distribution and brain localization of opioid-binding,cell adhesion (OBCAM) in the adult rats by immunoblotting and immunohistochemistry using a monoclonal anti-OBCAM peptide antibody that is specific for OBCAM. OBCAM was preferentially expressed in the central nervous system (CNS) and at a very low level in the spleen. Within the brain, OBCAM was distributed in almost all the gray matter, but little or no immunoreactive OBCAM was found in the white matter. Morphologically, the distribution pattern of OBCAM immunoreactivity was very similar to that of synaptophysin, suggesting a role in the synaptic machinery. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：482 / 486

页数：5

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