FcεR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells

被引：156

作者：

Qiao, HH ^{[1
]}

Andrade, MV ^{[1
]}

Lisboa, FA ^{[1
]}

Morgan, K ^{[1
]}

Beaven, MA ^{[1
]}

机构：

[1] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

来源：

BLOOD | 2006年 / 107卷 / 02期

关键词：

D O I：

10.1182/blood-2005-06-2271

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mast cells mediate both IgE-dependent allergic reactions and protective responses against acute infections, possibly through the activation of Toll-like receptors (TLRs). We find that antigen interacts synergistically with TLR2 and TLR4 ligands to markedly enhance production of cytokines in murine mast cell lines. However, the TLR ligands neither stimulated degranulation and release of arachidonic acid nor influenced such responses to antigen, probably because these ligands failed to generate a necessary calcium signal. The enhanced cytokine production could be attributed to synergistic activation of mitogen-activated protein kinases in addition to the engagement of a more effective repertoire of transcription factors for cytokine gene transcription. The synergistic interactions of TLR ligands and antigen might have relevance to the exacerbation of IgE-mediated allergic diseases by infectious agents.

引用

页码：610 / 618

页数：9

共 66 条

[21] PROLACTIN INDUCES PHOSPHORYLATION OF TYR694 OF STAT5 (MGF), A PREREQUISITE FOR DNA-BINDING AND INDUCTION OF TRANSCRIPTION [J].