Implications of Salmonella-induced nitric oxide (NO) for host defense and vaccines:: NO, an antimicrobial, antitumor, immunosuppressive and immunoregulatory molecule

Attenuated Salmonella induce immunosuppressive, microbicidal and tumoricidal macrophages in mice. All three effects are mediated by activated macrophages producing nitric oxide (NO). NO is induced by the innate immune response pathway involving IL-12, NK cells and IFN-gamma in response to infection. NO has beneficial and detrimental effects on the host. (C) 2001 Editions scientifiques et medicales Elsevier SAS.