Implications of Salmonella-induced nitric oxide (NO) for host defense and vaccines:: NO, an antimicrobial, antitumor, immunosuppressive and immunoregulatory molecule

被引：52

作者：

Eisenstein, TK

机构：

[1] Temple Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19140 USA

[2] Temple Univ, Sch Med, Ctr Subst Abuse Res, Philadelphia, PA 19140 USA

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 14-15期

关键词：

nitric oxide; immunosuppression; tumor immunity; IL-12; natural killer cells;

D O I：

10.1016/S1286-4579(01)01482-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Attenuated Salmonella induce immunosuppressive, microbicidal and tumoricidal macrophages in mice. All three effects are mediated by activated macrophages producing nitric oxide (NO). NO is induced by the innate immune response pathway involving IL-12, NK cells and IFN-gamma in response to infection. NO has beneficial and detrimental effects on the host. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

收藏

页码：1223 / 1231

页数：9

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