BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator

被引：974

作者：

Moore, PA ^{[1
]}

Belvedere, O ^{[1
]}

Orr, A ^{[1
]}

Pieri, K ^{[1
]}

LaFleur, DW ^{[1
]}

Feng, P ^{[1
]}

Soppet, D ^{[1
]}

Charters, M ^{[1
]}

Gentz, R ^{[1
]}

Parmelee, D ^{[1
]}

Li, YL ^{[1
]}

Galperina, O ^{[1
]}

Giri, J ^{[1
]}

Roschke, V ^{[1
]}

Nardelli, B ^{[1
]}

Carrell, J ^{[1
]}

Sosnovtseva, S ^{[1
]}

Greenfield, W ^{[1
]}

Ruben, SM ^{[1
]}

Olsen, HS ^{[1
]}

Fikes, J ^{[1
]}

Hilbert, DM ^{[1
]}

机构：

[1] Human Genome Sci, Rockville, MD 20850 USA

来源：

SCIENCE | 1999年 / 285卷 / 5425期

关键词：

D O I：

10.1126/science.285.5425.260

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The tumor necrosis factor (INF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B Lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-Lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.

引用

收藏

页码：260 / 263

页数：4

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