Cognitive effects of neurotoxic lesions of the nucleus basalis magnocellularis in rats: Differential roles for corticopetal versus amygdalopetal projections

被引:8
作者
Beninger, Richard J. [1 ,2 ]
Dringenberg, Hans C. [1 ]
Boegman, Roland J. [3 ]
Jhamandas, Khem [3 ]
机构
[1] Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada
[2] Queens Univ, Dept Psychiat, Kingston, ON K7L 3N6, Canada
[3] Queens Univ, Dept Pharmacol & Toxicol, Kingston, ON K7L 3N6, Canada
基金
英国医学研究理事会;
关键词
192; IgG-saporin; amygdala; cholinergic hypothesis; cortex; ibotenic acid; memory; nucleus basalis magnocellularis; quisqualic acid; review;
D O I
10.1007/BF03033227
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The cholinergic hypothesis states that cholinergic neurons of the basal forebrain nucleus basalis magnocellularis (nbm) that project to cortical and amy-gdalar targets play an important role in memory. Biochemical studies have shown that these target areas are differentially sensitive to different excitotoxins (e.g., ibotenate vs. quisqualate). This observation might explain the finding from many behavioural studies of memory that different excito-toxins affect memory differentially even though they produce about the same level of depletion of cholinergic markers in the cortex and similar cortical electrophysiological effects. Thus, the magnitude of mnemonic impairment might be related to the extent of damage to cholinergic projections to the amygdala more than to the extent of damage to corticopetal cholinergic projections. This explanation might similarly apply to the observation that the immunotoxin 192 IgG-saporin produces mild effects on memory when injected into the nbm. This is because it damages cholinergic neurons projecting to the cortex but not those projecting to the amygdala. Studies comparing the effects on memory of ibotenic acid vs. quisqualic acid lesions of the nbm are reviewed as are studies of the mnemonic effects of 192 IgG-saporin. Results support the cholinergic hypothesis and suggest that amygdalopetal cholinergic neurons of the nbm play an important role in the control of memory.
引用
收藏
页码:7 / 21
页数:15
相关论文
共 71 条
  • [11] QUISQUALATE LESIONS OF RAT NBM - SELECTIVE EFFECTS ON WORKING MEMORY IN A DOUBLE Y-MAZE
    BIGGAN, SL
    BENINGER, RJ
    COCKHILL, J
    JHAMANDAS, K
    BOEGMAN, RJ
    [J]. BRAIN RESEARCH BULLETIN, 1991, 26 (04) : 613 - 616
  • [12] Boegman R. J., 1992, Society for Neuroscience Abstracts, V18, P445
  • [13] QUINOLINIC ACID NEUROTOXICITY IN THE NUCLEUS BASALIS ANTAGONIZED BY KYNURENIC ACID
    BOEGMAN, RJ
    ELDEFRAWY, SR
    JHAMANDAS, K
    BENINGER, RJ
    LUDWIN, SK
    [J]. NEUROBIOLOGY OF AGING, 1985, 6 (04) : 331 - 336
  • [14] EXCITOTOXIC LESIONS OF RAT BASAL FOREBRAIN - DIFFERENTIAL-EFFECTS ON CHOLINE-ACETYLTRANSFERASE IN THE CORTEX AND AMYGDALA
    BOEGMAN, RJ
    COCKHILL, J
    JHAMANDAS, K
    BENINGER, RJ
    [J]. NEUROSCIENCE, 1992, 51 (01) : 129 - 135
  • [15] Buzsaki G, 1989, EXS, V57, P159
  • [16] CHOLINERGIC PROJECTIONS FROM THE BASAL FOREBRAIN TO THE BASOLATERAL AMYGDALOID COMPLEX - A COMBINED RETROGRADE FLUORESCENT AND IMMUNOHISTOCHEMICAL STUDY
    CARLSEN, J
    ZABORSZKY, L
    HEIMER, L
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1985, 234 (02) : 155 - 167
  • [17] BEHAVIORAL IMPAIRMENTS AFTER LESIONS OF THE NUCLEUS BASALIS BY IBOTENIC ACID AND QUISQUALIC ACID
    CONNOR, DJ
    LANGLAIS, PJ
    THAL, LJ
    [J]. BRAIN RESEARCH, 1991, 555 (01) : 84 - 90
  • [18] ALZHEIMERS-DISEASE - A DISORDER OF CORTICAL CHOLINERGIC INNERVATION
    COYLE, JT
    PRICE, DL
    DELONG, MR
    [J]. SCIENCE, 1983, 219 (4589) : 1184 - 1190
  • [19] THE ROLE OF CHOLINERGIC PROJECTIONS FROM THE NUCLEUS BASALIS IN MEMORY
    DEKKER, AJAM
    CONNOR, DJ
    THAL, LJ
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1991, 15 (02) : 299 - 317
  • [20] Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin
    Dornan, WA
    McCampbell, AR
    Tinkler, GP
    Hickman, LJ
    Bannon, AW
    Decker, MW
    Gunther, KL
    [J]. BEHAVIOURAL BRAIN RESEARCH, 1996, 82 (01) : 93 - 101