The gift of gab

被引：169

作者：

Liu, Y ^{[1
]}

Rohrschneider, LR ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

来源：

FEBS LETTERS | 2002年 / 515卷 / 1-3期

关键词：

Gab; tyrosine phosphorylation; receptor tyrosine kinase; signal transduction; differentiation;

D O I：

10.1016/S0014-5793(02)02425-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules involved in multiple signaling pathways mediated by receptor tyrosine kinases (RTKs) and non-RTK receptors. This paper reviews the structure/function relationships of Gab proteins and their biological roles during normal growth, differentiation and development programs. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：1 / 7

页数：7

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