Are the structures of SarA and SarR similar?

被引：6

作者：

Cheung, AL ^{[1
]}

Zhang, GY

机构：

[1] Dartmouth Coll Sch Med, Dept Microbiol, Hanover, NH 03755 USA

[2] Univ Colorado, Sch Med, Dept Pharmacol, Natl Jewish Med & Res Ctr,Dept Immunol, Denver, CO 80286 USA

来源：

TRENDS IN MICROBIOLOGY | 2001年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0966-842X(01)02253-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Staphylococcus aureus, the production of virulence determinants including hemolysin is controlled by global regulators such as SarA. Recently the crystal structures of SarA and SarR, a SarA homolog and a member of the SarA family of proteins, were solved. A motif found in SarR is similar to that found in the winged-helix protein family, and it is possible that the SarA family of proteins uses DNA bending to regulate gene transcription.

引用

页码：570 / 573

页数：4

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