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Insulin action in thee polycystic ovary syndrome

被引：110
作者：
Dunaif, A
机构：
[1] Brigham & Womens Hosp, Div Womens Hlth, Dept Med, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Div Womens Hlth, Dept Obstet & Gynecol, Boston, MA 02115 USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1999年 / 28卷 / 02期
关键词：
D O I：
10.1016/S0889-8529(05)70073-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Polycystic ovary syndrome is associated with profound insulin resistance, conferring an approximately 7-fold increased risk for type 2 diabetes mellitus in premenopausal women. The mechanisms of insulin resistance in PCOS are distinct from those in obesity and in typical type 2 diabetes mellitus. There also is evidence for pancreatic beta-cell dysfunction in PCOS that can occur independent of obesity and glucose intolerance. Insulin resistance contributes to the reproductive abnormalities of PCOS.
引用
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页码：341 / +
页数：20
相关论文
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