Insulin action in thee polycystic ovary syndrome

被引：110

作者：

Dunaif, A

机构：

[1] Brigham & Womens Hosp, Div Womens Hlth, Dept Med, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Div Womens Hlth, Dept Obstet & Gynecol, Boston, MA 02115 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1999年 / 28卷 / 02期

关键词：

D O I：

10.1016/S0889-8529(05)70073-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polycystic ovary syndrome is associated with profound insulin resistance, conferring an approximately 7-fold increased risk for type 2 diabetes mellitus in premenopausal women. The mechanisms of insulin resistance in PCOS are distinct from those in obesity and in typical type 2 diabetes mellitus. There also is evidence for pancreatic beta-cell dysfunction in PCOS that can occur independent of obesity and glucose intolerance. Insulin resistance contributes to the reproductive abnormalities of PCOS.

引用

页码：341 / +

页数：20

共 57 条

[11] EXCESSIVE INSULIN-RECEPTOR SERINE PHOSPHORYLATION IN CULTURED FIBROBLASTS AND IN SKELETAL-MUSCLE - A POTENTIAL MECHANISM FOR INSULIN-RESISTANCE IN THE POLYCYSTIC-OVARY-SYNDROME
DUNAIF, A
XIA, JR
BOOK, CB
SCHENKER, E
TANG, ZC
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (02) : 801 - 810
[12] PROFOUND PERIPHERAL INSULIN RESISTANCE, INDEPENDENT OF OBESITY, IN POLYCYSTIC OVARY SYNDROME
DUNAIF, A
SEGAL, KR
FUTTERWEIT, W
DOBRJANSKY, A
[J]. DIABETES, 1989, 38 (09) : 1165 - 1174
[13] beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome
Dunaif, A
Finegood, DT
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (03) : 942 - 947
[14] EVIDENCE FOR DISTINCTIVE AND INTRINSIC DEFECTS IN INSULIN ACTION IN POLYCYSTIC-OVARY-SYNDROME
DUNAIF, A
SEGAL, KR
SHELLEY, DR
GREEN, G
DOBRJANSKY, A
LICHOLAI, T
[J]. DIABETES, 1992, 41 (10) : 1257 - 1266
[15] Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
Dunaif, A
[J]. ENDOCRINE REVIEWS, 1997, 18 (06) : 774 - 800
[16] The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome
Dunaif, A
Scott, D
Finegood, D
Quintana, B
Whitcomb, R
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (09) : 3299 - 3306
[17] INSULIN ADMINISTRATION ALTERS GONADAL-STEROID METABOLISM INDEPENDENT OF CHANGES IN GONADOTROPIN-SECRETION IN INSULIN-RESISTANT WOMEN WITH THE POLYCYSTIC OVARY SYNDROME
DUNAIF, A
GRAF, M
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (01) : 23 - 29
[18] SUPPRESSION OF HYPERANDROGENISM DOES NOT IMPROVE PERIPHERAL OR HEPATIC INSULIN RESISTANCE IN THE POLYCYSTIC OVARY SYNDROME
DUNAIF, A
GREEN, G
FUTTERWEIT, W
DOBRJANSKY, A
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (03) : 699 - 704
[19] CHARACTERIZATION OF GROUPS OF HYPERANDROGENIC WOMEN WITH ACANTHOSIS NIGRICANS, IMPAIRED GLUCOSE-TOLERANCE, AND - OR HYPERINSULINEMIA
DUNAIF, A
GRAF, M
MANDELI, J
LAUMAS, V
DOBRJANSKY, A
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 65 (03) : 499 - 507
[20] DUNAIF A, 1997, 57 ANN SCI M AM DIAB

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