Highly Enantioselective Aza-Henry Reaction of Ketoimines Catalyzed by Chiral N,N′-Dioxide-Copper(I) Complexes

被引:101
作者
Tan, Cheng [1 ]
Liu, Xiaohua [1 ]
Wang, Liwei [1 ]
Wang, Jun [1 ]
Feng, Xiaoming [1 ,2 ]
机构
[1] Sichuan Univ, Key Lab Green Chem & Technol, Minist Educ, Coll Chem, Chengdu 610064, Peoples R China
[2] Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
基金
中国国家自然科学基金;
关键词
D O I
10.1021/ol802236h
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The first example of catalytic enantioselective aza-Henry reaction of ketoimines has been realized using a simple chiral N,N'-dioxide-Cu(I) complex as catalyst. It performs well over a range of substrates to give the corresponding products in moderate to good yields (up to 83%) with high enantioselectivities (up to 96% ee).
引用
收藏
页码:5305 / 5308
页数:4
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