Highly Enantioselective Aza-Henry Reaction of Ketoimines Catalyzed by Chiral N,N′-Dioxide-Copper(I) Complexes

被引：101

作者：

Tan, Cheng ^{[1
]}

Liu, Xiaohua ^{[1
]}

Wang, Liwei ^{[1
]}

Wang, Jun ^{[1
]}

Feng, Xiaoming ^{[1
,2
]}

机构：

[1] Sichuan Univ, Key Lab Green Chem & Technol, Minist Educ, Coll Chem, Chengdu 610064, Peoples R China

[2] Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 22期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/ol802236h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of catalytic enantioselective aza-Henry reaction of ketoimines has been realized using a simple chiral N,N'-dioxide-Cu(I) complex as catalyst. It performs well over a range of substrates to give the corresponding products in moderate to good yields (up to 83%) with high enantioselectivities (up to 96% ee).

引用

页码：5305 / 5308

页数：4

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