HCMV infection: Modulating the cell cycle and cell death

被引:35
作者
Castillo, JP [1 ]
Kowalik, TF [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Program Immunol & Virol, Worcester, MA 01655 USA
关键词
herpesvirus; cytomegalovirus; cell cycle; apoptosis; immune evasion;
D O I
10.1080/08830180490265565
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human cytomegalovirus (HCMV) is a member of the Herpesviridae family and is recognized as a significant pathogen to certain subgroups of the human population. It has become apparent that HCMV manipulation of the host cell cycle as well as the immune response promotes the replication and propagation of the virus. The ability of HCMV to modulate components of the host immune system and the response to infection most likely contributes to the pathology associated with this virus. This review will address the mechanisms HCMV has adapted to modulate the cell cycle to promote viral replication as well as the different ways it can prevent the "death" of an infected cell.
引用
收藏
页码:113 / 139
页数:27
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