Oxidized protein degradation and repair in ageing and oxidative stress

被引：179

作者：

Friguet, Bertrand ^{[1
]}

机构：

[1] Univ Paris 07, Lab Biol & Biochim Cellulaire Vieillissement, IFR 117, EA 3106, F-75005 Paris, France

来源：

FEBS LETTERS | 2006年 / 580卷 / 12期

关键词：

oxidized protein; ageing; oxidative stress; proteasome; lon protease; methionine sulfoxide reductase;

D O I：

10.1016/j.febslet.2006.03.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular ageing is characterized by the accumulation of oxidatively modified proteins which may be due to increased protein damage and/or decreased elimination of oxidized protein. Since the proteasome is in charge of protein turnover and removal of oxidized protein, its fate during ageing and upon oxidative stress has received special attention, and evidence has been provided for an age-related impairment of proteasome function. However, proteins when oxidized at the level of sulfur-containing amino acids can also be repaired. Therefore, the fate of the methionine sulfoxide reductase system during ageing has also been addressed as well as its role in protection against oxidative stress. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2910 / 2916

页数：7

共 70 条

[1] Dietary self-selection can compensate an age-related decrease of rat liver 20 S proteasome activity observed with standard diet [J].