Ruthenium-Catalyzed Highly Regioselective Cyclization of Ketoximes with Alkynes by C-H Bond Activation: A Practical Route to Synthesize Substituted Isoquinolines

被引：220

作者：

Chinnagolla, Ravi Kiran ^{[1
]}

Pimparkar, Sandeep ^{[1
]}

Jeganmohan, Masilamani ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Dept Chem, Pune 411021, Maharashtra, India

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 12期

关键词：

ONE-POT SYNTHESIS; INTERNAL ALKYNES; PYRIDINE-DERIVATIVES; DIRECTING GROUP; O BOND; FUNCTIONALIZATION; ANNULATION; IMINOANNULATION; HETEROCYCLES; SALTS;

D O I：

10.1021/ol301091z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aromatic and heteroaromatic ketoximes underwent cyclization with alkynes in the presence of a catalytic amount of [{RuCl2(p-cymene)}(2)] and NaOAc to give isoquinoline derivatives in good to excellent yields in a highly regioselective manner.

引用

页码：3032 / 3035

页数：4

共 47 条

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