Phase II trial of carboplatin plus oral etoposide for elderly patients with small-cell lung cancer

被引：35

作者：

Matsui, K

Masuda, N

Fukuoka, M

Yana, T

Hirashima, T

Komiya, T

Kobayashi, M

Kawahara, M

Atagi, S

Ogawara, M

Negoro, S

Kudoh, S

Furuse, K

机构：

[1] Osaka Prefectural Habikino Hosp, Dept Internal Med 2, Habikino, Osaka 583, Japan

[2] Osaka City Gen Hosp, Dept Resp Dis, Miyakojima Ku, Osaka 534, Japan

[3] Natl Kinki Cent Hosp, Dept Internal Med, Sakai, Osaka 591, Japan

[4] Osaka City Univ, Sch Med, Dept Internal Med 1, Osaka 545, Japan

来源：

BRITISH JOURNAL OF CANCER | 1998年 / 77卷 / 11期

关键词：

elderly patients; small-cell lung cancer; etoposide; carboplatin; Egorin's formula;

D O I：

10.1038/bjc.1998.325

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A phase II trial was conducted to evaluate the efficacy and toxicity of the Egorin's carboplatin dosing formula with 14-day oral etoposide in 38 elderly patients with small-cell lung cancer (SCLC). The overall response rate was 81%. Median survival times were 15.1 months for 16 limited-disease (LD) and 8.6 months for 22 extensive-disease (ED) patients. Myelosuppression was the principal side-effect. This regimen is an active regimen in the treatment of elderly SCLC patients.

引用

页码：1961 / 1965

页数：5

共 32 条

[1]

AISNER J, 1983, CANCER TREAT REP, V67, P37

[2] CARBOPLATIN (CBDCA, JM-8) AND VP-16-213 IN PREVIOUSLY UNTREATED PATIENTS WITH SMALL-CELL LUNG-CANCER [J].

BISHOP, JF ;

RAGHAVAN, D ;

STUARTHARRIS, R ;

MORSTYN, G ;

ARONEY, R ;

KEFFORD, R ;

YUEN, K ;

LEE, J ;

GIANOUTSOS, P ;

OLVER, IN ;

ZALCBERG, J ;

BALL, D ;

BULL, C ;

FOX, R .

JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (10) :1574-1578

[3] CARBOPLATIN DOSAGE - PROSPECTIVE EVALUATION OF A SIMPLE FORMULA BASED ON RENAL-FUNCTION [J].

CALVERT, AH ;

NEWELL, DR ;

GUMBRELL, LA ;

OREILLY, S ;

BURNELL, M ;

BOXALL, FE ;

SIDDIK, ZH ;

JUDSON, IR ;

GORE, ME ;

WILTSHAW, E .

JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (11) :1748-1756

[4] CARBOPLATIN/ETOPOSIDE COMBINATION CHEMOTHERAPY IN THE TREATMENT OF POOR-PROGNOSIS PATIENTS WITH SMALL-CELL LUNG-CANCER [J].

CARNEY, DN .

LUNG CANCER, 1995, 12 :S77-S83

[5]

CARNEY DN, 1990, SEMIN ONCOL, V17, P49

[6]

CAVALLI F, 1978, CANCER TREAT REP, V62, P473

[7] PREDICTION OF CARBOPLATIN CLEARANCE FROM STANDARD MORPHOLOGICAL AND BIOLOGICAL PATIENT CHARACTERISTICS [J].

CHATELUT, E ;

CANAL, P ;

BRUNNER, V ;

CHEVREAU, C ;

PUJOL, A ;

BONEU, A ;

ROCHE, H ;

HOUIN, G ;

BUGAT, R .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (08) :573-580

[8]

CLARK PI, 1990, P AN M AM SOC CLIN, V9, P226

[9]

Dajczman E, 1996, CANCER, V77, P2032, DOI 10.1002/(SICI)1097-0142(19960515)77:10<2032::AID-CNCR10>3.3.CO

[10]

2-Q

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