Phase II trial of carboplatin plus oral etoposide for elderly patients with small-cell lung cancer

被引：35

作者：

Matsui, K

Masuda, N

Fukuoka, M

Yana, T

Hirashima, T

Komiya, T

Kobayashi, M

Kawahara, M

Atagi, S

Ogawara, M

Negoro, S

Kudoh, S

Furuse, K

机构：

[1] Osaka Prefectural Habikino Hosp, Dept Internal Med 2, Habikino, Osaka 583, Japan

[2] Osaka City Gen Hosp, Dept Resp Dis, Miyakojima Ku, Osaka 534, Japan

[3] Natl Kinki Cent Hosp, Dept Internal Med, Sakai, Osaka 591, Japan

[4] Osaka City Univ, Sch Med, Dept Internal Med 1, Osaka 545, Japan

来源：

BRITISH JOURNAL OF CANCER | 1998年 / 77卷 / 11期

关键词：

elderly patients; small-cell lung cancer; etoposide; carboplatin; Egorin's formula;

D O I：

10.1038/bjc.1998.325

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A phase II trial was conducted to evaluate the efficacy and toxicity of the Egorin's carboplatin dosing formula with 14-day oral etoposide in 38 elderly patients with small-cell lung cancer (SCLC). The overall response rate was 81%. Median survival times were 15.1 months for 16 limited-disease (LD) and 8.6 months for 22 extensive-disease (ED) patients. Myelosuppression was the principal side-effect. This regimen is an active regimen in the treatment of elderly SCLC patients.

引用

页码：1961 / 1965

页数：5

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