Global Longitudinal Strain Predicts Long-Term Survival in Patients With Chronic Ischemic Cardiomyopathy

Background-Left ventricular (LV) global longitudinal strain (GLS) is a measure of the active shortening of the LV in the longitudinal direction, which can be assessed with speckle-tracking echocardiography. The aims of this evaluation were to validate the prognostic value of GLS as a new index of LV systolic function in a large cohort of patients with chronic ischemic cardiomyopathy and to determine the incremental value of GLS to predict long-term outcome over other strong and well-established prognostic factors. Methods and Results-A total of 1060 patients underwent baseline clinical evaluation and transthoracic echocardiography. Median age was 66.9 years (interquartile range, 58.4, 74.2 years); 739 (70%) were men. The median follow-up duration for the entire patient population was 31 months. During the follow-up, 270 patients died and 309 patients reached the combined end point (all-cause mortality and heart failure hospitalization). Compared with survivors, patients who died (270, [25%]) had larger LV volumes (P < 0.05), lower LV ejection fraction (P = 0.004), higher wall motion score index (P = 0.001), and greater impairment of LV GLS (P < 0.001). After dichotomizing the population on the basis of the median value of LV GLS (-11.5%), patients with an LV GLS <=-11.5% had superior outcome compared with patients with an LV GLS >-11.5% (log-rank chi(2), 13.86 and 14.16 for all-cause mortality and combined end point, respectively, P < 0.001 for both). On multivariate analysis, GLS was independently related to all-cause mortality (hazard ratio per 5% increase, 1.69; 95% confidence interval, 1.33-2.15; P < 0.001) and combined end point (1.64; 95% confidence interval, 1.32-2.04; P < 0.001). Conclusions-The assessment of LV GLS with speckle-tracking echocardiography is significantly related to long-term outcome in patients with chronic ischemic cardiomyopathy. (Circ Cardiovasc Imaging. 2012;5:383-391.)