MAPKAP kinases - MKs - two's company, three's a crowd

被引：318

作者：

Gaestel, M ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Biochem, D-30625 Hannover, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 02期

关键词：

D O I：

10.1038/nrm1834

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs)-MK2, MK3 and MK5-signal to diverse cellular targets. Although there is no known common function for all three MKs, these kinases are involved in important processes: MKs regulate gene expression at the transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle progression, and are implicated in inflammation and cancer.

引用

页码：120 / 130

页数：11

共 116 条

[21] AU-RICH ELEMENTS - CHARACTERIZATION AND IMPORTANCE IN MESSENGER-RNA DEGRADATION [J].

CHEN, CYA ;

SHYU, AB .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (11) :465-470

[22]

Cheng TJ, 1998, J CELL BIOCHEM, V71, P169

[23] Two distinct forms of MAPKAP kinase-2 in adult cardiac ventricular myocytes [J].

Chevalier, D ;

Allen, BG .

BIOCHEMISTRY, 2000, 39 (20) :6145-6156

[24] MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding [J].

Chrestensen, CA ;

Schroeder, MJ ;

Shabanowitz, J ;

Hunt, DF ;

Pelo, JW ;

Worthington, MT ;

Sturgill, TW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (11) :10176-10184

[25] A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress [J].

Clifton, AD ;

Young, PR ;

Cohen, P .

FEBS LETTERS, 1996, 392 (03) :209-214

[26] Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation [J].

Coulombe, P ;

Rodier, G ;

Pelletier, S ;

Pellerin, J ;

Meloche, S .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (13) :4542-4558

[27] THE RCK1 AND RCK2 PROTEIN-KINASE GENES FROM SACCHAROMYCES-CEREVISIAE SUPPRESS CELL-CYCLE CHECKPOINT MUTATIONS IN SCHIZOSACCHAROMYCES-POMBE [J].

DAHLKVIST, A ;

KANTERSMOLER, G ;

SUNNERHAGEN, P .

MOLECULAR AND GENERAL GENETICS, 1995, 246 (03) :316-326

[28] Discovery and characterization of a substrate selective p38α inhibitor [J].

Davidson, W ;

Frego, L ;

Peet, GW ;

Kroe, RR ;

Labadia, ME ;

Lukas, SM ;

Snow, RJ ;

Jakes, S ;

Grygon, CA ;

Pargellis, C ;

Werneburg, BG .

BIOCHEMISTRY, 2004, 43 (37) :11658-11671

[29] Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics [J].

Dreiza, CM ;

Brophy, CM ;

Komalavilas, P ;

Furnish, EJ ;

Joshi, L ;

Pallero, MA ;

Murphy-Ullrich, JE ;

von Rechenberg, M ;

Ho, YSJ ;

Richardson, B ;

Xu, NF ;

Zhen, YJ ;

Peltier, JM ;

Panitch, A .

FASEB JOURNAL, 2004, 18 (15) :261-+

[30] Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation [J].

Ehrnsperger, M ;

Graber, S ;

Gaestel, M ;

Buchner, J .

EMBO JOURNAL, 1997, 16 (02) :221-229

← 1 2 3 4 5 6 7 8 9 10 →