Preparations of antifungal Sch 42427/SM 9164: Preparative chromatographic resolution, and total asymmetric synthesis via enzymatic preparation of chiral alpha-hydroxy arylketones.

被引：68

作者：

Gala, D

DiBenedetto, DJ

Clark, JE

Murphy, BL

Schumacher, DP

Steinman, M

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07033

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 05期

关键词：

D O I：

10.1016/0040-4039(95)02234-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient approaches towards the preparation of chiral azole antifungals Sch 42427/ SM 9164 (1) via large scale chromatographic separation of its enantiomers, or via enzymatic syntheses of key chiral intermediates alpha-hydroxy arylketones 5 in excellent enantiomeric excesses (ees) are described.

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页码：611 / 614

页数：4

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