DECOMPOSITION OF ALPHA-HYDROXYARYL KETONES AND CHARACTERIZATION OF SOME UNUSUAL PRODUCTS

被引：6

作者：

GALA, D

PUAR, MS

DAS, PR

KUGELMAN, M

DIBENEDETTO, DJ

机构：

[1] Schering Plough Research Institute, Bloomfield, New Jersey, 07003

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1992年 / 81卷 / 12期

关键词：

D O I：

10.1002/jps.2600811215

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alpha-hydroxyaryl ketones such as 2-hydroxypropiophenone and 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone, the key intermediates in the preparation of antifungal agents, decompose into oxidized, rearranged, and condensed products. These products were isolated and characterized. The possible mechanisms for the formation of the products are discussed.

引用

页码：1199 / 1203

页数：5

共 24 条

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