Interlaboratory variation in the detection of clinically significant alloantibodies against human platelet alloantigens

被引：42

作者：

Metcalfe, P

Allen, D

Chapman, J

Ouwehand, WH

机构：

[1] NATL BLOOD SERV OXFORD,JOHN RADCLIFFE HOSP,OXFORD,ENGLAND

[2] ST BARTHOLOMEWS HOSP,ROYAL HOSP NHS TRUST,LONDON,ENGLAND

[3] UNIV CAMBRIDGE,NATL BOOD SERV LONDON & S E,DIV TRANSFUS MED,CAMBRIDGE,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 97卷 / 01期

关键词：

human platelet alloantigens; anti-HPA-1a; antibody detection; neonatal alloimmune thrombocytopenia;

D O I：

10.1046/j.1365-2141.1997.9992647.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This report describes the results eight workshop exercises which were designed to test the proficiency of laboratories in the detection of antibodies to, human platelet antigens (HPA). Detection of the most clinically significant alloantibody, anti-HPA-1a, is adequate. However, despite improvements in consistency of test results between laboratories over the last 3 years, there is still a high probability that clinically significant antibodies against other HPA alloantigens will not be detected.

引用

页码：204 / 207

页数：4

共 7 条

[1] SENSITIVITY OF THE PLATELET IMMUNOFLUORESCENCE TEST (PIFT) AND THE MAIPA ASSAY FOR THE DETECTION OF PLATELET-REACTIVE ALLOANTIBODIES - A REPORT ON 2 UK NATIONAL PLATELET WORKSHOP EXERCISES [J].