Sorbicillinol, a key intermediate of bisorbicillinoid biosynthesis in Trichoderma sp USF-2690

被引：39

作者：

Abe, N ^{[1
]}

Sugimoto, O ^{[1
]}

Arakawa, T ^{[1
]}

Tanji, K ^{[1
]}

Hirota, A ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Food & Nutr Sci, Shizuoka 4228526, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 10期

关键词：

sorbicillinol; DPPH-radical scavenger; Trichoderma sp USF-2690; bisorbicillinoids biosynthesis;

D O I：

10.1271/bbb.65.2271

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the course of our screening program for free radical scavengers from Trichoderma sp. USF-2690, we found an unidentified metabolite (1) that appeared by the method used for HPLC analysis. Metabolite 1 gradually decreased with the production of bisorbicillinoids and was easily missed during the general isolation procedure. The LC-ESI-MS (negative) analysis for I gave m/z 247 as the (M-1)(-) ion peak. The hydrolysis of synthetic 6-O-acetylsorbicillinol (+/- -2) by 0.05 M KOH and acetylation of product I in an aqueous solution indicated that the structure of 1 was (6S)-4-(2,4-hexadienoyl)-3,6-dihydroxy-2,6-dimethyl-2,4- cyclohexadien-1-one, designated sorbicillinol, a quinol that has been postulated to be important in bisorbicillinoid biosynthesis.

引用

页码：2271 / 2279

页数：9

共 19 条

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