Novel oxidized sorbicillin dimers with 1,1-diphenyl-2-picrylhydrazyl-radical scavenging activity from a fungus

被引：69

作者：

Abe, N ^{[1
]}

Murata, T ^{[1
]}

Hirota, A ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Food & Nutr Sci, Appl Microbiol Lab, Shizuoka 4228526, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1998年 / 62卷 / 11期

关键词：

DPPH-radical scavenger; Trichoderma sp. USF-2690; bisorbibutenolide; bisorbicillinolide; oxidized sorbicillin dimer;

D O I：

10.1271/bbb.62.2120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three yellowish compounds with 1,1-diphenyl-2-picryl-hydrazyl-radical scavenging activity were newly isolated from the fermentation broth of Trichoderma sp. USF-2690 strain that had been isolated from a soil sample: two were novel oxidized sorbicillin dimers designated as bisorbicillinolide (1) and bisorbicillinolide (2), and one was sorbicillin (3) itself. The structures of 1 and 2 were determined from spectroscopic evidence. In the DPPH-radical scavenging assay, alpha-tocopherol gave an ED50 value of 17.0 mu M after standing for 30 min, white continuing observation showed that the ED50 values for bisorbibutenolide, bisorbicillinolide, and sorbicillin slowly reached 80.8, 88.8 and 152.3 mu M over 24 hr.

引用

页码：2120 / 2126

页数：7

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