Ansamycin antibiotics as free radical scavengers isolated from Streptomyces by using the bactericidal action of the hydroxyl radical

被引：11

作者：

Morimitsu, Y ^{[1
]}

Hirota, A ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH FOOD & NUTR SCI, APPL MICROBIOL LAB, SHIZUOKA 422, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 09期

关键词：

radical scavenger; Fenton reaction; bactericidal action; Streptomyces; ansamycin antibiotics;

D O I：

10.1271/bbb.60.1507

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ansamycin antibiotics (1-4) were isolated from the cultured broth of Streptomyces sp. USF-319 strain as a result of our screening for free radical scavengers. They inhibited the bactericidal effect of the Fenton reagent toward Bacillus subtilis by their radical scavenging activity. Some of them also showed inhibitory activity against lipid peroxidation and lipoxygenases.

引用

页码：1507 / 1509

页数：3

共 19 条

[1] DETERMINATION OF PEROXYL RADICAL-SCAVENGING ACTIVITY IN FOOD BY USING BACTERICIDAL ACTION OF ALKYL PEROXYL RADICAL [J].

AKAIKE, T ;

IJIRI, S ;

SATO, K ;

KATSUKI, T ;

MAEDA, H .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1995, 43 (07) :1864-1870

[2]

ARUOMA OI, 1989, J BIOL CHEM, V264, P20509

[3] ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL [J].

BLOIS, MS .

NATURE, 1958, 181 (4617) :1199-1200

[4] REDUCTION AND RELEASE OF FERRITIN IRON BY PLANT PHENOLICS [J].

BOYER, RF ;

CLARK, HM ;

LAROCHE, AP .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1988, 32 (03) :171-181

[5]

Buege J A, 1978, Methods Enzymol, V52, P302

[6] NEW LIQUID-CHROMATOGRAPHY APPROACH TO PLANT PHENOLICS - APPLICATION TO DETERMINATION OF CHLOROGENIC ACID IN SUNFLOWER MEAL [J].

FELICE, LJ ;

KING, WP ;

KISSINGER, PT .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1976, 24 (02) :380-382

[7] PEROXIDE-DEPENDENT AND PEROXIDE-INDEPENDENT LIPID PEROXIDATIONS CATALYZED BY CHELATED IRON [J].

FUKUZAWA, K ;

FUJII, T ;

MUKAI, K .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1991, 290 (02) :489-496

[8] STRUCTURE OF TRIENOMYCIN-A, A NOVEL CYTOCIDAL ANSAMYCIN ANTIBIOTIC [J].

FUNAYAMA, S ;

OKADA, K ;

KOMIYAMA, K ;

UMEZAWA, I .

JOURNAL OF ANTIBIOTICS, 1985, 38 (08) :1107-1109

[9] STRUCTURES OF TRIENOMYCINS A, B AND C, NOVEL CYTOCIDAL ANSAMYCIN ANTIBIOTICS [J].

FUNAYAMA, S ;

OKADA, K ;

IWASAKI, K ;

KOMIYAMA, K ;

UMEZAWA, I .

JOURNAL OF ANTIBIOTICS, 1985, 38 (12) :1677-1683

[10] OXYGEN RADICALS IN THE ADULT RESPIRATORY-DISTRESS SYNDROME, IN MYOCARDIAL ISCHEMIA AND REPERFUSION INJURY, AND IN CEREBRAL VASCULAR DAMAGE [J].

HAMMOND, B ;

KONTOS, HA ;

HESS, ML .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1985, 63 (03) :173-187

← 1 2 →