Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus

被引：186

作者：

Ueno, T

Hara, K

Willis, MS

Malin, MA

Höpken, UE

Gray, DHD

Matsushima, K

Lipp, M

Springer, TA

Boyd, RL

Yoshie, O

Takahama, Y ^{[1
]}

机构：

[1] Univ Tokushima, Inst Genome Res, Div Expt Immunol, Tokushima 7708503, Japan

[2] RIKEN, Res Ctr Allergy & Immunol, Lab Immune Syst Dev, Tokushima 7708503, Japan

[3] Kinki Univ, Sch Med, Dept Microbiol, Osaka 5890014, Japan

[4] Univ Tokyo, Sch Med, Dept Mol Prevent Med, Tokyo 1130033, Japan

[5] Max Delbruck Ctr Mol Med, Dept Mol Tumorgenet & Immunogenet, Berlin, Germany

[6] Monash Univ, Sch Med, Dept Pathol & Immunol, Prahran, Vic 3181, Australia

[7] Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA

来源：

IMMUNITY | 2002年 / 16卷 / 02期

关键词：

D O I：

10.1016/S1074-7613(02)00267-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most T lymphocytes are generated within the thymus. It is unclear, however, how newly generated T cells relocate out of the thymus to the circulation. The present study shows that a CC chemokine CCL19 attracts mature T cells out of the fetal thymus organ culture. Another CC chemokine CCL21, which shares CCR7 with CCL19 but has a unique C-terminal extension containing positively charged amino acids, failed to show involvement in thymic emigration. Neonatal appearance of circulating T cells was defective in CCL19-neutralized mice as well as in CCR7-deficient mice but not in CCL21-neutralized mice. In the thymus, CCL19 is predominantly localized in the medulla including endothelial venules. These results indicate a CCL19- and CCR7-dependent pathway of thymic emigration, which represents a major pathway of neonatal T cell export.

引用

页码：205 / 218

页数：14

共 53 条

[1] Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: Possible implications for negative selection [J].