Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes

被引：114

作者：

Blaschke, F

Takata, Y

Caglayan, E

Law, RE

Hsueh, WA

机构：

[1] Univ Calif Los Angeles, Div Endocrinol Diabet & Hypertens, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] German Heart Inst, Dept Med Cardiol, Berlin, Germany

[3] Takeda Pharmaceut N Amer Inc, Lincolnshire, IL USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2006年 / 26卷 / 01期

关键词：

PPARs; atherosclerosis; obesity; diabetes;

D O I：

10.1161/01.ATV.0000191663.12164.77

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. The 3 PPAR isotypes, PPAR-alpha, PPAR-gamma, and PPAR-delta, play a key role in the regulation of lipid and glucose metabolism. Obesity and the interrelated disorders of the metabolic syndrome have become a major worldwide health problem. In this review, we summarize the critical role of PPARs in regulating inflammation, lipoprotein metabolism, and glucose homeostasis and their potential implications for the treatment of obesity, diabetes, and atherosclerosis.

引用

收藏

页码：28 / 40

页数：13

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