Lymphoblastic lymphoma expressing natural killer cell phenotype with involvement of the mediastinum and nasal cavity

被引：52

作者：

Koita, H

Suzumiya, J

Ohshima, K

Takeshita, M

Kimura, N

Kikuchi, M

Koono, M

机构：

[1] MIYAZAKI PREFECTURAL NOBEOKA HOSP,DEPT PATHOL,NOBEOKA,MIYAZAKI,JAPAN

[2] FUKUOKA UNIV,SCH MED,DEPT INTERNAL MED 1,JONAN KU,FUKUOKA 81401,JAPAN

[3] FUKUOKA UNIV,SCH MED,DEPT PATHOL 1,JONAN KU,FUKUOKA 81401,JAPAN

[4] MIYAZAKI MED COLL,DEPT PATHOL 2,KIYOTAKE,MIYAZAKI,JAPAN

来源：

AMERICAN JOURNAL OF SURGICAL PATHOLOGY | 1997年 / 21卷 / 02期

关键词：

lymphoblastic lymphoma; natural killer cell; nasal lymphoma; CD56;

D O I：

10.1097/00000478-199702000-00016

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Most CD56+ lymphomas display polymorphic and angiocentric/angiodestructive histologic features and are closely related to Epstein-Barr virus (EBV) infection. We report a 47-year-old Japanese man with CD56+ lymphoma that showed histologic features of lymphoblastic lymphoma with mediastinal and nasal involvement and an aggressive course. A sample specimen showed the histology of lymphoblastic lymphoma with a positive reaction for terminal deoxynucleotidyl transferase (TdT) but no angiocentric/angiodestructive features. Transmission electron microscopy revealed a few membrane-bound electron-dense granules in their cytoplasm. Immunohistochemically, lymphoma cells exhibited CD56+ cytoplasmic CD3 (cCD3)+ TdT+. A Southern blot analysis showed no integration of EBV and human T-lymphotrophic virus 1 (HTLV-I) and no rearrangement of the T-cell receptors or immunoglobulin heavy chain genes. This unusual lymphoblastic lymphoma exhibiting cCD3+CD56+TdT+TCR- is assumed as an immature or progenitor natural killer cell lineage.

引用

页码：242 / 248

页数：7

共 50 条

[11] PATHOLOGIC AND CLINICAL SPECTRUM OF POST-THYMIC T-CELL MALIGNANCIES [J].

JAFFE, ES .

CANCER INVESTIGATION, 1984, 2 (05) :413-426

[12] Report of the workshop on nasal and related extranodal angiocentric T natural killer cell lymphomas - Definitions, differential diagnosis, and epidemiology [J].

Jaffe, ES ;

Chan, JKC ;

Su, IJ ;

Frizzera, G ;

Mori, S ;

Feller, AC ;

Ho, FCS .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (01) :103-111

[13]

KANAVAROS P, 1993, BLOOD, V81, P2688

[14] NOVEL LEUKEMIC LYMPHOMA WITH PROBABLE DERIVATION FROM IMMATURE STAGE OF NATURAL-KILLER (NK) LINEAGE IN AN AGED PATIENT [J].

KAWANO, S ;

TATSUMI, E ;

YONEDA, N ;

YAMAGUCHI, N ;

GOJI, J ;

ITO, H ;

NAGAI, T ;

NISHIKORI, M ;

OKAMURA, A ;

KOIWAI, O .

HEMATOLOGICAL ONCOLOGY, 1995, 13 (01) :1-11

[15]

KERN WF, 1992, BLOOD, V79, P2432

[16]

KIMURA N, 1989, CANCER RES, V49, P4488

[17]

KIMURA N, 1994, P 25 C INT SOC HEM C

[18] THE DEVELOPMENTAL RELATIONSHIP BETWEEN NK CELLS AND T-CELLS [J].

LANIER, LL ;

SPITS, H ;

PHILLIPS, JH .

IMMUNOLOGY TODAY, 1992, 13 (10) :392-395

[19]

LENNERT K, 1992, HISTOPATHOLOGY NONHO, P244

[20]

LINK MP, 1983, BLOOD, V61, P838

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