Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro

Spontaneous aggregation of A beta is a key factor in the development of Alzheimer's disease. In searching for A beta aggregation inhibitors from traditional Chinese herbal medicines, we identified two active compounds from Psoraleae Fructus, namely isobavachalcone and bavachinin. We further demonstrated that the two compounds modulate A beta 42 aggregation process through different mechanisms. Isobavachalcone significantly inhibits both oligomerization and fibrillization of A beta 42, whereas bavachinin inhibits fibrillization and leads to off-pathway aggregation. Both of the compounds attenuated A beta 42-induced toxicity in a SH-SY5Y cell model. These findings may provide valuable information for new drug development and Alzheimer's therapy in the future. Structured digital abstract: Abeta42 physically interacts with Abeta42 by two hybrid (View interaction) Abeta42 and Abeta42 bind by filter binding (View interaction) Abeta42 and Abeta42 bind by comigration in sds page (1, 2, 3) Abeta42 and Abeta42 bind by atomic force microscopy (View interaction) Abeta42 and Abeta42 bind by fluorescence technology (View interaction) (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.