Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses

被引：189

作者：

Russell, Colin A. ^{[1
]}

Jones, Terry C. ^{[1
,2
,3
]}

Barr, Ian G. ^{[4
]}

Cox, Nancy J. ^{[5
]}

Garten, Rebecca J. ^{[5
]}

Gregory, Vicky ^{[6
]}

Gust, Ian D. ^{[4
]}

Hampson, Alan W. ^{[4
]}

Hay, Alan J. ^{[6
]}

Hurt, Aeron C. ^{[4
]}

de Jong, Jan C. ^{[1
,2
]}

Kelso, Anne ^{[4
]}

Klimov, Alexander I. ^{[5
]}

Kageyama, Tsutomu ^{[7
]}

Komadina, Naomi ^{[4
]}

Lapedes, Alan S. ^{[8
]}

Lin, Yi P. ^{[6
]}

Mosterin, Ana ^{[1
,3
]}

Obuchi, Masatsugu ^{[7
]}

Odagiri, Takato ^{[7
]}

Osterhaus, Albert D. M. E. ^{[1
,2
]}

Rimmelzwaan, Guus F. ^{[1
,2
]}

Shaw, Michael W. ^{[5
]}

Skepner, Eugene ^{[1
]}

Stohri, Klaus ^{[9
]}

Tashiro, Masato ^{[7
]}

Fouchier, Ron A. M. ^{[1
,2
]}

Smith, Derek J. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

[2] Erasmus MC, Dept Virol, Rotterdam, Netherlands

[3] Univ Pompeu Fabra, Barcelona, Spain

[4] WHO, Collaborating Ctr Reference & Res Influenza, Melbourne, Vic, Australia

[5] WHO, Collaborating Ctr Influenza, Ctr Dis Control & Prevent, Atlanta, GA USA

[6] WHO, Collaborating Ctr Influenza, Natl Inst Med Res, London, England

[7] WHO, Collaborating Ctr Influenza, Natl Inst Infect Dis, Tokyo, Japan

[8] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA

[9] Novartis Vaccines & Diagnost, Cambridge, MA USA

来源：

VACCINE | 2008年 / 26卷

基金：

英国医学研究理事会;

关键词：

influenza; Vaccine strain selection; Seasonal influenza viruses;

D O I：

10.1016/j.vaccine.2008.07.078

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Annual influenza epidemics in humans affect 5-15% of the population, causing an estimated half million deaths worldwide per year [Stohr K. Influenza-WHO cares. Lancet Infectious Diseases 2002;2(9):517]. The virus can infect this proportion of people year after year because the virus has an extensive capacity to evolve and thus evade the immune response. For example, since the influenza A(H3N2) subtype entered the human population in 1968 the A(H3N2) component of the influenza vaccine has had to be updated almost 30 times to track the evolution of the viruses and remain effective. The World Health Organization Global Influenza Surveillance Network (WHO GISN) tracks and analyzes the evolution and epidemiology of influenza viruses for the primary purpose of vaccine strain selection and to improve the strain selection process through studies aimed at better understanding virus evolution and epidemiology. Here we give an overview of the strain selection process and outline recent investigations into the global migration of seasonal influenza viruses. (c) 2008 Published by Elsevier Ltd.

引用

页码：D31 / D34

页数：4

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