Intracellular pH regulation in heart

被引：242

作者：

Vaughan-Jones, Richard D. ^{[1
]}

Spitzer, Kenneth W. ^{[2
]}

Swietach, Pawel ^{[1
]}

机构：

[1] Burdon Sanderson Cardiac Sci Ctr, Dept Physiol Anat & Genet, Oxford OX1 3PT, England

[2] Univ Utah, NE Harrison Cardiovasc Res & Training Inst, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2009年 / 46卷 / 03期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

Cardiac; Heart; Myocyte; pH(i); NHE; NBC; CHE; CBE; H+; OH-; HCO3-; Arrhythmia; Contraction; Cardioprotection; RAT VENTRICULAR MYOCYTES; CARBONIC-ANHYDRASE-II; NA+/H+ EXCHANGER NHE1; SODIUM-HYDROGEN-EXCHANGE; NH2-TERMINAL CYTOPLASMIC DOMAIN; CARDIAC PURKINJE-FIBERS; H+-ION MOBILITY; ELECTROGENIC NA+-HCO3-COTRANSPORT; ACTIVATED PROTEIN-KINASE; SLOW FORCE RESPONSE;

D O I：

10.1016/j.yjmcc.2008.10.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Intracellular pH (pH(i)) is an important modulator of cardiac excitation and contraction, and a potent trigger of electrical arrhythmia. This review outlines the intracellular and membrane mechanisms that control pHi in the cardiac myocyte. We consider the kinetic regulation of sarcolemmal H+, OH- and HCO3- transporters by pH, and by receptor-coupled intracellular signalling systems. We also consider how activity of these pH(i) effector proteins is coordinated spatially in the myocardium by intracellular mobile buffer shuttles, gap junctional channels and carbonic anhydrase enzymes. Finally, we review the impact of pH(i) regulatory proteins on intracellular Ca2+ signalling, and their participation in clinical disorders such as myocardial ischaemia, maladaptive hypertrophy and heart failure. Such multiple effects emphasise the fundamental role that pHi regulation plays in the heart (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：318 / 331

页数：14

共 168 条

[1] Evidence for an electrogenic Na+-HCO3- symport in rat cardiac myocytes [J].

Aiello, EA ;

Petroff, NGV ;

Mattiazzi, AR ;

Cingolani, HE .

JOURNAL OF PHYSIOLOGY-LONDON, 1998, 512 (01) :137-148

[2] THE EFFECTS OF CHANGES OF PH ON INTRACELLULAR CALCIUM TRANSIENTS IN MAMMALIAN CARDIAC-MUSCLE [J].

ALLEN, DG ;

ORCHARD, CH .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 335 (FEB) :555-567

[3] Role of the cardiac Na+ /H+ exchanger during ischemia and reperfusion [J].

Allen, DG ;

Xiao, XH .

CARDIOVASCULAR RESEARCH, 2003, 57 (04) :934-941

[4] Molecular physiology of SLC4 anion exchangers [J].

Alper, SL .

EXPERIMENTAL PHYSIOLOGY, 2006, 91 (01) :153-161

[5] Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy [J].

Alvarez, Bernardo V. ;

Johnson, Danielle E. ;

Sowah, Daniel ;

Soliman, Daniel ;

Light, Peter E. ;

Xia, Ying ;

Karmazyn, Morris ;

Casey, Joseph R. .

JOURNAL OF PHYSIOLOGY-LONDON, 2007, 579 (01) :127-145

[6] Mechanisms underlying the increase in force and Ca2+ transient that follow stretch of cardiac muscle -: A possible explanation of the Anrep effect [J].

Alvarez, BV ;

Pérez, NG ;

Ennis, IL ;

de Hurtado, MCC ;

Cingolani, HE .

CIRCULATION RESEARCH, 1999, 85 (08) :716-722

[7] Slc26a6: a cardiac chloride-hydroxyl exchanger and predominant chloride-bicarbonate exchanger of the mouse heart [J].

Alvarez, BV ;

Kieller, DM ;

Quon, AL ;

Markovich, D ;

Casey, JR .

JOURNAL OF PHYSIOLOGY-LONDON, 2004, 561 (03) :721-734

[8] Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter [J].

Alvarez, BV ;

Loiselle, FB ;

Supuran, CT ;

Schwartz, GJ ;

Casey, JR .

BIOCHEMISTRY, 2003, 42 (42) :12321-12329

[9] Metabolon disruption: a mechanism that regulates bicarbonate transport [J].

Alvarez, BV ;

Vilas, GL ;

Casey, JR .

EMBO JOURNAL, 2005, 24 (14) :2499-2511

[10] MODIFIER ROLE OF INTERNAL H+ IN ACTIVATING THE NA+-H+ EXCHANGER IN RENAL MICROVILLUS MEMBRANE-VESICLES [J].

ARONSON, PS ;

NEE, J ;

SUHM, MA .

NATURE, 1982, 299 (5879) :161-163

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