A Missing Link in Genotype-Directed Cancer Therapy

被引：81

作者：

Bernards, Rene ^{[1
,2
]}

机构：

[1] Netherlands Canc Inst, Div Mol Carcinogenesis, Ctr Biomed Genet, NL-1066 CX Amsterdam, Netherlands

[2] Netherlands Canc Inst, Canc Genom Ctr, NL-1066 CX Amsterdam, Netherlands

来源：

CELL | 2012年 / 151卷 / 03期

关键词：

INHIBITION; VEMURAFENIB; EGFR;

D O I：

10.1016/j.cell.2012.10.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genotype-directed therapy holds great promise for the treatment of cancer, but crosstalk between signaling pathways often confounds simple genotype-drug response relationships. To deliver on the promise of precision medicine, a coordinated effort is needed to make a comprehensive inventory of the many signaling feedback circuits that exist in cancer cells.

引用

页码：465 / 468

页数：4

共 9 条

[1]

[Anonymous], 2011, PREC MED BUILD KNOWL

[2] AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity [J].

Chandarlapaty, Sarat ;

Sawai, Ayana ;

Scaltriti, Maurizio ;

Rodrik-Outmezguine, Vanessa ;

Grbovic-Huezo, Olivera ;

Serra, Violeta ;

Majumder, Pradip K. ;

Baselga, Jose ;

Rosen, Neal .

CANCER CELL, 2011, 19 (01) :58-71

[3] Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation [J].

Chapman, Paul B. ;

Hauschild, Axel ;

Robert, Caroline ;

Haanen, John B. ;

Ascierto, Paolo ;

Larkin, James ;

Dummer, Reinhard ;

Garbe, Claus ;

Testori, Alessandro ;

Maio, Michele ;

Hogg, David ;

Lorigan, Paul ;

Lebbe, Celeste ;

Jouary, Thomas ;

Schadendorf, Dirk ;

Ribas, Antoni ;

O'Day, Steven J. ;

Sosman, Jeffrey A. ;

Kirkwood, John M. ;

Eggermont, Alexander M. M. ;

Dreno, Brigitte ;

Nolop, Keith ;

Li, Jiang ;

Nelson, Betty ;

Hou, Jeannie ;

Lee, Richard J. ;

Flaherty, Keith T. ;

McArthur, Grant A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (26) :2507-2516

[4] EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of BRAF-Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib [J].

Corcoran, Ryan B. ;

Ebi, Hiromichi ;

Turke, Alexa B. ;

Coffee, Erin M. ;

Nishino, Michiya ;

Cogdill, Alexandria P. ;

Brown, Ronald D. ;

Della Pelle, Patricia ;

Dias-Santagata, Dora ;

Hung, Kenneth E. ;

Flaherty, Keith T. ;

Piris, Adriano ;

Wargo, Jennifer A. ;

Settleman, Jeffrey ;

Mino-Kenudson, Mari ;

Engelman, Jeffrey A. .

CANCER DISCOVERY, 2012, 2 (03) :227-235

[5] Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer [J].

Duncan, James S. ;

Whittle, Martin C. ;

Nakamura, Kazuhiro ;

Abell, Amy N. ;

Midland, Alicia A. ;

Zawistowski, Jon S. ;

Johnson, Nancy L. ;

Granger, Deborah A. ;

Jordan, Nicole Vincent ;

Darr, David B. ;

Usary, Jerry ;

Kuan, Pei-Fen ;

Smalley, David M. ;

Major, Ben ;

He, Xiaping ;

Hoadley, Katherine A. ;

Zhou, Bing ;

Sharpless, Norman E. ;

Perou, Charles M. ;

Kim, William Y. ;

Gomez, Shawn M. ;

Chen, Xin ;

Jin, Jian ;

Frye, Stephen V. ;

Earp, H. Shelton ;

Graves, Lee M. ;

Johnson, Gary L. .

CELL, 2012, 149 (02) :307-321

[6] The concept of synthetic lethality in the context of anticancer therapy [J].

Kaelin, WG .

NATURE REVIEWS CANCER, 2005, 5 (09) :689-698

[7] Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR [J].

Prahallad, Anirudh ;

Sun, Chong ;

Huang, Sidong ;

Di Nicolantonio, Federica ;

Salazar, Ramon ;

Zecchin, Davide ;

Beijersbergen, Roderick L. ;

Bardelli, Alberto ;

Bernards, Rene .

NATURE, 2012, 483 (7387) :100-U146

[8] Clinical application of pharmacogenetics [J].

Spear, BB ;

Heath-Chiozzi, M ;

Huff, J .

TRENDS IN MOLECULAR MEDICINE, 2001, 7 (05) :201-204

[9] Cancer: Addiction to oncogenes - The Achilles heal of cancer [J].

Weinstein, IB .

SCIENCE, 2002, 297 (5578) :63-64

← 1 →