Treatment of Eosinophilic Esophagitis: Overview, Current Limitations, and Future Direction

被引：35

作者：

Bohm, Matthew ^{[1
]}

Richter, Joel E. ^{[2
,3
]}

机构：

[1] Temple Univ, Sch Med, Dept Med, Philadelphia, PA 19122 USA

[2] Temple Univ, Sch Med, Dept Gastroenterol, Philadelphia, PA 19122 USA

[3] Temple Univ, Sch Med, Dept Med, Philadelphia, PA 19122 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2008年 / 103卷 / 10期

关键词：

D O I：

10.1111/j.1572-0241.2008.02116.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Eosinophilic esophagitis (EE) is an increasingly recognized syndrome presenting with upper gastrointestinal (UGI) symptoms in association with hypereosinophilia (>15 eosinophils/HPF) on esophageal mucosal biopsies. The pathogenesis is unknown, but the candidate etiologies include food and aeroallergen hypersensitivity and an unusual presentation of gastroesophageal reflux disease. This review will highlight the treatments of EE in children and adults. Current treatments are controversial, few data are available in adults, and long-term studies are almost nonexistent. We outline the limitations in the current studies and suggest seven major issues in the study design that must be addressed in future drug trials. (Am J Gastroenterol 2008;103:2635-2644)

引用

页码：2635 / 2644

页数：10

共 46 条

[21] Primary eosinophilic esophagitis in children: Successful treatment with oral corticosteroids [J].

Liacouras, CA ;

Wenner, WJ ;

Brown, K ;

Ruchelli, E .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1998, 26 (04) :380-385

[22]

Markowitz JE, 2003, AM J GASTROENTEROL, V98, P777, DOI 10.1111/j.1572-0241.2003.07390.x

[23] Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism [J].

Mishra, A ;

Rothenberg, ME .

GASTROENTEROLOGY, 2003, 125 (05) :1419-1427

[24] An etiological role for aeroallergens and eosinophils in experimental esophagitis [J].

Mishra, A ;

Hogan, SP ;

Brandt, EB ;

Rothenberg, ME .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (01) :83-90

[25] IL-5 promotes eosinophil trafficking to the esophagus [J].

Mishra, A ;

Hogan, SP ;

Brandt, EB ;

Rothenberg, ME .

JOURNAL OF IMMUNOLOGY, 2002, 168 (05) :2464-2469

[26]

Morrow JB, 2001, AM J GASTROENTEROL, V96, P984

[27] Eosinophils in the esophagus - Peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophilia [J].

Ngo, P ;

Furuta, GT ;

Antonioli, DA ;

Fox, VL .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2006, 101 (07) :1666-1670

[28] Clinical and Immunopathologic Effects of Swallowed Fluticasone for Eosinophilic Esophagitis [J].

Noel, Richard J. ;

Putnam, Philip E. ;

Collins, Margaret H. ;

Assa'ad, Amal H. ;

Guajardo, Jesus R. ;

Jameson, Sean C. ;

Rothenberg, Marc E. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2004, 2 (07) :568-575

[29] Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients [J].

Parfitt, JR ;

Gregor, JC ;

Suskin, NG ;

Jawa, HA ;

Driman, DK .

MODERN PATHOLOGY, 2006, 19 (01) :90-96

[30]

Pasha SF, 2006, CURR OPIN INVEST DR, V7, P992

← 1 2 3 4 5 →