A Ratiometric Fluorescent Probe for Hypochlorite Based on a Deoximation Reaction

被引：257

作者：

Lin, Weiying ^{[1
]}

Long, Lingliang ^{[1
]}

Chen, Bingbing ^{[1
]}

Tan, Wen ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2009年 / 15卷 / 10期

基金：

美国国家科学基金会;

关键词：

charge transfer; fluorescence spectroscopy; fluorescent probes; hypochlorite; ratiometric; CARBONYL-COMPOUNDS; ACID; OXIMES; MYELOPEROXIDASE; SEMICARBAZONES; REGENERATION; HYDRAZONES; DISEASE; STRESS; CANCER;

D O I：

10.1002/chem.200802054

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we have successfully provided a novel strategy for the rational design and synthesis of a ratiometric fluorescent probe for hypochlorite, The strategy is based on the deoximation reaction, which has not yet been used in the fluorescent hypochlorite probe design. Interestingly, the probe showed a ratiometric fluorescent response to hypochlorite with the emission intensities ratio increasing from 0.28 to 2.74. Furthermore, the probe displayed high selectivity for hypochlorite over other species due to the distinct deoximation conditions. The probe developed herein represents the first ratiometric fluorescent probe for hypochlorite.

引用

页码：2305 / 2309

页数：5

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[11] (E)-phenyl- and -heteroaryl-substituted 0-benzoyl- (or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors [J].