p53 mutations in two patients with intraductal papillary adenoma of the pancreas

被引：14

作者：

Kaino, M ^{[1
]}

Kondoh, S ^{[1
]}

Okita, S ^{[1
]}

Ryozawa, S ^{[1
]}

Hatano, S ^{[1
]}

Shiraishi, K ^{[1
]}

Kaino, S ^{[1
]}

Akiyama, T ^{[1
]}

Okita, K ^{[1
]}

Kawano, T ^{[1
]}

机构：

[1] HOFU INST GASTROENTEROL,HOFU,YAMAGUCHI 747,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1996年 / 87卷 / 12期

关键词：

p53; mutation; pancreas; intraductal adenoma; tumorigenesis;

D O I：

10.1111/j.1349-7006.1996.tb03132.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There has been no report on p53 gene mutation in benign human pancreatic intraductal tumors. We examined pancreatic juice and tissue specimens from two patients with intraductal papillary adenoma of the pancreas by polymerase chain reaction-single-strand conformation polymorphism analysis and direct sequencing and found point mutations of p53 gene resulting in amino acid substitutions in exons 6 and 8. Thus, p53 gene mutation may be an early event in the neoplastic process of some pancreatic intraductal tumors and may play an important role in tumorigenesis.

引用

页码：1195 / 1198

页数：4

共 16 条

[1] ABNORMALITIES OF THE P53 TUMOR SUPPRESSOR GENE IN HUMAN PANCREATIC-CANCER [J].