Respiratory impedance is correlated with morphological changes in the lungs on three-dimensional CT in patients with COPD

被引：38

作者：

Karayama, Masato ^{[1
,2
]}

Inui, Naoki ^{[1
,3
]}

Mori, Kazutaka ^{[1
]}

Kono, Masato ^{[1
]}

Hozumi, Hironao ^{[1
]}

Suzuki, Yuzo ^{[1
]}

Furuhashi, Kazuki ^{[1
]}

Hashimoto, Dai ^{[1
]}

Enomoto, Noriyuki ^{[1
]}

Fujisawa, Tomoyuki ^{[1
]}

Nakamura, Yutaro ^{[1
]}

Watanabe, Hiroshi ^{[3
]}

Suda, Takafumi ^{[1
]}

机构：

[1] Hamamatsu Univ, Sch Med, Dept Internal Med, Div 2, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

[2] Hamamatsu Univ, Sch Med, Dept Clin Oncol, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

[3] Hamamatsu Univ, Sch Med, Dept Clin Pharmacol & Therapeut, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

FORCED OSCILLATION TECHNIQUE; EXPIRATORY FLOW LIMITATION; COMPUTED-TOMOGRAPHY ASSESSMENT; AIRWAY WALL THICKNESS; IMPULSE OSCILLOMETRY; RESISTANCE; EMPHYSEMA; REACTANCE; DIMENSIONS; SMOKERS;

D O I：

10.1038/srep41709

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The forced oscillation technique provides information concerning respiratory impedance, which comprises resistance and reactance of the respiratory system. However, its relationship with morphological changes of the lungs in chronic obstructive pulmonary disease (COPD) remains unclear. Respiratory impedance and spirometric data were evaluated in 98 patients with COPD and 49 reference subjects. Wall thickness (WT) and airway intraluminal area (Ai) of third-to sixth-generation bronchi, and percentage low-attenuation area with less than -950 HU (%LAA) of lungs were measured using three-dimensional computed tomography. COPD patients had higher respiratory impedance, decreased Ai, and increased %LAA compared with reference subjects. Indices of respiratory resistance and reactance and forced expiratory volume in 1 second (FEV1) were correlated with Ai, and the association between percent predicted FEV1 and Ai was predominant in distal bronchi. The difference in respiratory resistance between 5 Hz and 20 Hz (R5-R20) and FEV1/forced vital capacity ratio (FEV1/FVC) were correlated with WT.The % LAA was correlated with the FEV1/FVC ratio and respiratory reactance. Airway function measurements with the forced oscillation technique provide complementary information to spirometry in COPD.

引用

页数：8

共 34 条

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