Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry

被引:15
作者
Fukuda, T
Kobayashi, T
Yasui, H
Tsutsumi, M
Konishi, Y
Hino, O
机构
[1] Inst Canc Res, Dept Expt Pathol, Toshima Ku, Tokyo 1708455, Japan
[2] Nara Med Univ, Ctr Canc, Dept Oncol Pathol, Kashihara, Nara 6348521, Japan
关键词
Tsc2; protein; renal cell carcinoma; Eker rat; tuberous sclerosis;
D O I
10.1007/s004280050350
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Alterations in the rat tuberous sclerosis gene (Tsc2) are responsible for the hereditary renal carcinomas (RCs) of Eker rat. We examined protein distribution in various normal fat tissues and the Eker RCs by immunohistochemistry. Tsc3 protein is expressed in the mammary ducts, salivary glands, gastric glands, parathyroid, small and large intestine, ovary and uterus. Specific expression of Tsc2 protein is found in the B cells of pancreatic islets and in the smooth muscle of lung veins. Interestingly, in the RCs of Eker rat, Tsc2 protein was detectable with some variation in reactivity.
引用
收藏
页码:341 / 350
页数:10
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