A NOVEL CANCER PREDISPOSITION SYNDROME IN THE EKER RAT MODEL

被引：34

作者：

HINO, O

MITANI, H

KATSUYAMA, H

KUBO, Y

机构：

[1] Department of Experimental Pathology, Cancer Institute, Toshima-ku, Tokyo, 170

来源：

CANCER LETTERS | 1994年 / 83卷 / 1-2期

关键词：

HEREDITARY CANCER; 2-HIT MODEL; ANIMAL MODEL; TUMOR SUPPRESSOR GENE; TUMOR SPECTRUM;

D O I：

10.1016/0304-3835(94)90307-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hereditary renal carcinomas (RCs) develop in virtually all Eker rats by the age of one year. Investigation of extrarenal primary tumors occurring in Eker rats late in life (at 2 years) additionally revealed pituitary adenomas (17/31 = 54.8% (carrier) vs 7/32 = 21.9% (non-carrier siblings df affected animals), P < 0.01), sarcomas of the spleen (21/31 = 67.7% vs. 0/32 = 0%, P < 0.001) and sarcomas (of probable stromal origin) of the uterus (8/17 = 47.1% vs. 0/15 = 0%, P < 0.01). Thus, the Eker rat might provide a novel animal model of cancer predisposition syndromes.

引用

页码：117 / 121

页数：5

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