Diamonds in the rough: Protein crystals from a formulation perspective

被引：51

作者：

Jen, A ^{[1
]}

Merkle, HP ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Inst Pharmaceut Sci, Dept Appl Biosci, CH-8057 Zurich, Switzerland

来源：

PHARMACEUTICAL RESEARCH | 2001年 / 18卷 / 11期

关键词：

protein formulation; crystalline formulation; protein crystals; macromolecular crystallization;

D O I：

10.1023/A:1013057825942

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The focus of the present review is to address the use of protein crystals in formulation design. Although this idea has been present for some time, i.e., insulin crystals were first reported back in 1920s, macromolecular crystallization has not received as much attention as the other methods for stabilizing protein drug candidates. The prospective potential of crystalline protein formulations in light of new advances in the field of macromolecular crystallization was reviewed, and the basic concepts and the tools now available for developing protein crystals into drug formulations are introduced. In addition, formulation challenges and regulatory demands, along with examples of current applications of protein crystals, are presented.

引用

页码：1483 / 1488

页数：6

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