Innate Immune Sensing of HIV-1 by Dendritic Cells

被引：69

作者：

Luban, Jeremy ^{[1
,2
]}

机构：

[1] Univ Geneva, Dept Microbiol & Mol Med, CH-1211 Geneva, Switzerland

[2] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

来源：

CELL HOST & MICROBE | 2012年 / 12卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; AICARDI-GOUTIERES-SYNDROME; CD4(+) T-CELLS; RESTRICTION FACTOR SAMHD1; TOLL-LIKE RECEPTORS; HUMAN TRIM5-ALPHA; IN-VITRO; REVERSE-TRANSCRIPTASE; INFECTED INDIVIDUALS; ANTIGEN PRESENTATION;

D O I：

10.1016/j.chom.2012.10.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1-specific antibodies and CD8(+) cytotoxic T cells are detected in most HIV-1-infected people, yet HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus the inability to effectively including SAMHD1, TREX1, and TRIMS provide a molecular basis for understanding why DCs fail to adequately sense invasion by this deadly pathogen and suggest experimental approaches to improve T cell priming to HIV-1 in prophylactic vaccination protocols.

引用

页码：408 / 418

页数：11

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