Oocyte morphology correlates with embryo quality and pregnancy rate after intracytoplasmic sperm injection

被引:114
作者
Loutradis, D [1 ]
Drakakis, P [1 ]
Kallianidis, K [1 ]
Milingos, S [1 ]
Dendrinos, S [1 ]
Michalas, S [1 ]
机构
[1] Univ Athens, Sch Med, Dept Obstet & Gynecol 1, Alexandra Matern Hosp,IVF Unit, GR-11527 Athens, Greece
关键词
ICSI; oocyte morphology; embryo quality; pregnancy rate;
D O I
10.1016/S0015-0282(99)00233-2
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To evaluate the relation of oocyte morphology with embryo quality and pregnancy rates (PRs) after intracytoplasmic sperm injection (ICSI). Design: Retrospective study of patients undergoing ICSI. Setting: University Hospital IVF Center. Patient(s): Sixty-eight patients who underwent ICSI and had transfer of good-quality embryos (grade 3), 60 patients with transfer of both good- and poor-quality embryos (grade 3 and grade 2), and 18 patients with transfer of poor-quality embryos (grade 2). Intervention(s): Comparison of the outcome of ICSI in the three groups of patients and the relation of oocyte morphology to embryo quality. Main Outcome Measure(s): Oocyte morphology and embryo quality (grade). Fertilization, cleavage, and pregnancy rates. Serum E-2 on the day of hCG administration. Result(s): Oocytes with poor morphology (dark cytoplasm; many vacuoles or fragments in cytoplasm) led to poor-quality embryos and consequently to lower PRs (5.5% versus 29.4%). Serum E-2 on the day of hCG administration was significantly higher in the group with good-quality embryos compared with that with poor-quality embryos (2,047 +/- 135.7 versus 1,651 +/- 164.8 pg/mL, respectively). Conclusion(s): Serum E-2 on the day of hCG administration is a marker of embryo quality. Oocyte morphology correlates well with embryo quality and PRs after ICSI. (C) 1999 by American Society for Reproductive Medicine.
引用
收藏
页码:240 / 244
页数:5
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