Amplification of a cyclic mixed-metalloporphyrin tetramer from a dynamic combinatorial library through orthogonal metal coordination

被引:60
作者
Stulz, E [1 ]
Ng, YF [1 ]
Scott, SM [1 ]
Sanders, JKM [1 ]
机构
[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England
关键词
D O I
10.1039/b111019p
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A cyclic porphyrin tetramer, consisting of two bis-phosphine substituted zinc(II) porphyrin units and two Rh(III) TPP units, is selected and amplified virtually quantitatively from a dynamic combinatorial library using 4,4'-bipy as a scaffold and using orthogonal binding modes.
引用
收藏
页码:524 / 525
页数:2
相关论文
共 21 条
[1]  
Albrecht M, 1999, CHEM-EUR J, V5, P48, DOI 10.1002/(SICI)1521-3765(19990104)5:1<48::AID-CHEM48>3.3.CO
[2]  
2-Z
[3]   LIGAND-BINDING BY BUTADIYNE-LINKED PORPHYRIA DIMERS, TRIMERS AND TETRAMERS [J].
ANDERSON, HL ;
ANDERSON, S ;
SANDERS, JKM .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1995, (18) :2231-2245
[4]   Molecular evolution: dynamic combinatorial libraries, autocatalytic networks and the quest for molecular function [J].
Cousins, GRL ;
Poulsen, SA ;
Sanders, JKM .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (03) :270-279
[5]   Phosphine-substituted porphyrins as supramolecular building blocks [J].
Darling, SL ;
Stulz, E ;
Feeder, N ;
Bampos, N ;
Sanders, JKM .
NEW JOURNAL OF CHEMISTRY, 2000, 24 (05) :261-264
[6]   Chloroform-soluble Schiff-base Zn(II) or Cd(II) complexes from a dynamic combinatorial library [J].
Epstein, DM ;
Choudhary, S ;
Churchill, MR ;
Keil, KM ;
Eliseev, AV ;
Morrow, JR .
INORGANIC CHEMISTRY, 2001, 40 (07) :1591-1596
[7]  
Huc I, 1999, EUR J INORG CHEM, P1415
[8]   Dynamic diversity in drug discovery: Putting small-molecule evolution to work [J].
Karan, C ;
Miller, BL .
DRUG DISCOVERY TODAY, 2000, 5 (02) :67-75
[9]   RNA-selective coordination complexes identified via dynamic combinatorial chemistry [J].
Karan, C ;
Miller, BL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (30) :7455-7456
[10]   Assembly of dynamic heterometallic oligoporphyrins using cooperative zinc-nitrogen, ruthenium-nitrogen, and tin-oxygen coordination [J].
Kim, HJ ;
Bampos, N ;
Sanders, JKM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (35) :8120-8121